Zhu, X., A. Bagchi, H. Zhao, C. J. Kirschning, R. J. Hajjar, W. Chao, J. Hellman, and U. Schmidt
Toll-like receptor 2 activation by bacterial peptidoglycan-associated lipoprotein activates cardiomyocyte inflammation and contractile dysfunction.
Crit Care Med 35:886 2007
Zantl, N., G. Weirich, H. Zall, B. M. Seiffert, S. F. Fischer, S. Kirschnek, C. Hartmann, R. M. Fritsch, B. Gillissen, P. T. Daniel, and G. Hacker
Frequent loss of expression of the pro-apoptotic protein Bim in renal cell carcinoma: evidence for contribution to apoptosis resistance.
Oncogene 26:7038
Ying, S., and G. Hacker
Apoptosis induced by direct triggering of mitochondrial apoptosis proceeds in the near-absence of some apoptotic markers.
Apoptosis 12:2003
Wiethe, C., M. Schiemann, D. Busch, L. Haeberle, M. Kopf, G. Schuler, and M. B. Lutz
Interdependency of MHC class II/self-peptide and CD1d/self-glycolipid presentation by TNF-matured dendritic cells for protection from autoimmunity.
J Immunol 178:4908
Weber, A., S. A. Paschen, K. Heger, F. Wilfling, T. Frankenberg, H. Bauerschmitt, B. M. Seiffert, S. Kirschnek, H. Wagner, and G. Hacker
BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins.
J Cell Biol 177:625
Spiller, S., S. Dreher, G. Meng, A. Grabiec, W. Thomas, T. Hartung, K. Pfeffer, H. Hochrein, H. Brade, W. Bessler, H. Wagner, and C. J. Kirschning
Cellular recognition of trimyristoylated peptide or enterobacterial lipopolysaccharide via both TLR2 and TLR4.
J Biol Chem 282:13190
Schuster, I. G., D. H. Busch, E. Eppinger, E. Kremmer, S. Milosevic, C. Hennard, C. Kuttler, J. W. Ellwart, B. Frankenberger, E. Nossner, C. Salat, C. Bogner, A. Borkhardt, H. J. Kolb, and A. M. Krackhardt
Allorestricted T cells with specificity for the FMNL1-derived peptide PP2 have potent antitumor activity against hematologic and other malignancies.
Blood 110:2931
Schulz, C., A. Schafer, M. Stolla, S. Kerstan, M. Lorenz, M. L. von Bruhl, M. Schiemann, J. Bauersachs, T. Gloe, D. H. Busch, M. Gawaz, and S. Massberg
Chemokine fractalkine mediates leukocyte recruitment to inflammatory endothelial cells in flowing whole blood: a critical role for P-selectin expressed on activated platelets.
Circulation 116:764
Schmitz, F., A. Heit, S. Guggemoos, A. Krug, J. Mages, M. Schiemann, H. Adler, I. Drexler, T. Haas, R. Lang, and H. Wagner
Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells.
Eur J Immunol 37:315
Schleicher, U., J. Liese, I. Knippertz, C. Kurzmann, A. Hesse, A. Heit, J. A. Fischer, S. Weiss, U. Kalinke, S. Kunz, and C. Bogdan
NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs.
J Exp Med 204:893
Rupprecht, T. A., C. J. Kirschning, B. Popp, S. Kastenbauer, V. Fingerle, H. W. Pfister, and U. Koedel
Borrelia garinii induces CXCL13 production in human monocytes through Toll-like receptor 2.
Infect Immun 75:4351
Rubio-Aliaga, I., D. Soewarto, S. Wagner, M. Klaften, H. Fuchs, S. Kalaydjiev, D. H. Busch, M. Klempt, B. Rathkolb, E. Wolf, K. Abe, S. Zeiser, G. K. Przemeck, J. Beckers, and M. H. de Angelis
A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse.
Genetics 175:1451
Rodriguez, N., J. Mages, H. Dietrich, N. Wantia, H. Wagner, R. Lang, and T. Miethke
MyD88-dependent changes in the pulmonary transcriptome after infection with Chlamydia pneumoniae.
Physiol Genomics 30:134
Rad, R., L. Brenner, A. Krug, P. Voland, J. Mages, R. Lang, S. Schwendy, W. Reindl, A. Dossumbekova, W. Ballhorn, H. Wagner, R. M. Schmid, S. Bauer, and C. Prinz
Toll-like receptor-dependent activation of antigen-presenting cells affects adaptive immunity to Helicobacter pylori.
Gastroenterology 133:150
Paschen, S. A., A. Weber, and G. Hacker
Mitochondrial protein import: a matter of death?
Cell Cycle 6:2434
Oeder, S., J. Mages, P. Flicek, and R. Lang
Uncovering information on expression of natural antisense transcripts in Affymetrix MOE430 datasets.
BMC Genomics 8:200
Neuenhahn, M., and D. H. Busch
Unique functions of splenic CD8alpha(+) dendritic cells during infection with intracellular pathogens.
Immunol Lett
Neudorfer, J., B. Schmidt, K. M. Huster, F. Anderl, M. Schiemann, G. Holzapfel, T. Schmidt, L. Germeroth, H. Wagner, C. Peschel, D. H. Busch, and H. Bernhard
Reversible HLA multimers (Streptamers) for the isolation of human cytotoxic T lymphocytes functionally active against tumor- and virus-derived antigens.
J Immunol Methods 320:119
Merx, S., M. Neumaier, H. Wagner, C. J. Kirschning, and P. Ahmad-Nejad
Characterization and investigation of single nucleotide polymorphisms and a novel TLR2 mutation in the human TLR2 gene.
Hum Mol Genet 16:1225
Mayer, A. K., M. Muehmer, J. Mages, K. Gueinzius, C. Hess, K. Heeg, R. Bals, R. Lang, and A. H. Dalpke
Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells.
J Immunol 178:3134
Lin, Y. H., J. Friederichs, M. A. Black, J. Mages, R. Rosenberg, P. J. Guilford, V. Phillips, M. Thompson-Fawcett, N. Kasabov, T. Toro, A. E. Merrie, A. van Rij, H. S. Yoon, J. L. McCall, J. R. Siewert, B. Holzmann, and A. E. Reeve
Multiple gene expression classifiers from different array platforms predict poor prognosis of colorectal cancer.
Clin Cancer Res 13:498
Lepenies, B., J. P. Cramer, G. D. Burchard, H. Wagner, C. J. Kirschning, and T. Jacobs
Induction of experimental cerebral malaria is independent of TLR2/4/9.
Med Microbiol Immunol
Lech, M., C. Garlanda, A. Mantovani, C. J. Kirschning, D. Schlondorff, and H. J. Anders
Different roles of TiR8/Sigirr on toll-like receptor signaling in intrarenal antigen-presenting cells and tubular epithelial cells.
Kidney Int 72:182
Layland, L. E., R. Rad, H. Wagner, and C. U. da Costa
Immunopathology in schistosomiasis is controlled by antigen-specific regulatory T cells primed in the presence of TLR2.
Eur J Immunol 37:2174
Lahl, K., C. Loddenkemper, C. Drouin, J. Freyer, J. Arnason, G. Eberl, A. Hamann, H. Wagner, J. Huehn, and T. Sparwasser
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease.
J Exp Med 204:57
Krishnan, L., K. Gurnani, C. J. Dicaire, H. van Faassen, A. Zafer, C. J. Kirschning, S. Sad, and G. D. Sprott
Rapid clonal expansion and prolonged maintenance of memory CD8+ T cells of the effector (CD44highCD62Llow) and central (CD44highCD62Lhigh) phenotype by an archaeosome adjuvant independent of TLR2.
J Immunol 178:2396
Koedel, U., U. M. Merbt, C. Schmidt, B. Angele, B. Popp, H. Wagner, H. W. Pfister, and C. J. Kirschning
Acute brain injury triggers MyD88-dependent, TLR2/4-independent inflammatory responses
Am J Pathol 171:200
Klein, M., C. Schmidt, S. Kastenbauer, R. Paul, C. J. Kirschning, H. Wagner, B. Popp, H. W. Pfister, and U. Koedel
MyD88-dependent immune response contributes to hearing loss in experimental pneumococcal meningitis.
J Infect Dis 195:1189
Kastenmuller, W., G. Gasteiger, J. H. Gronau, R. Baier, R. Ljapoci, D. H. Busch, and I. Drexler
Cross-competition of CD8+ T cells shapes the immunodominance hierarchy during boost vaccination.
J Exp Med 204:2187
Kaiser-Schulz, G., A. Heit, L. Quintanilla-Martinez, F. Hammerschmidt, S. Hess, L. Jennen, H. Rezaei, H. Wagner, and H. M. Schatzl
Polylactide-coglycolide microspheres co-encapsulating recombinant tandem prion protein with CpG-oligonucleotide break self-tolerance to prion protein in wild-type mice and induce CD4 and CD8 T cell responses.
J Immunol 179:2797
Heit, A., F. Schmitz, T. Haas, D. H. Busch, and H. Wagner
Antigen co-encapsulated with adjuvants efficiently drive protective T cell immunity.
Eur J Immunol 37:2063
Heit, A., D. H. Busch, H. Wagner, and F. Schmitz
Vaccine protocols for enhanced immunogenicity of exogenous antigens
Int J Med Microbiol
Hamm, S., A. Heit, M. Koffler, K. M. Huster, S. Akira, D. H. Busch, H. Wagner, and S. Bauer
Immunostimulatory RNA is a potent inducer of antigen-specific cytotoxic and humoral immune response in vivo.
Int Immunol 19:297
Hacker, G., and A. Weber
BH3-only proteins trigger cytochrome c release, but how?
Arch Biochem Biophys 462:150
Hacker, G., and S. A. Paschen
Therapeutic targets in the mitochondrial apoptotic pathway.
Expert Opin Ther Targets 11:515
Habib, S. J., T. Waizenegger, A. Niewienda, S. A. Paschen, W. Neupert, and D. Rapaport
The N-terminal domain of Tob55 has a receptor-like function in the biogenesis of mitochondrial beta-barrel proteins.
J Cell Biol 176:77
Greten, F. R., M. C. Arkan, J. Bollrath, L. C. Hsu, J. Goode, C. Miething, S. I. Goktuna, M. Neuenhahn, J. Fierer, S. Paxian, N. Van Rooijen, Y. Xu, T. O’Cain, B. B. Jaffee, D. H. Busch, J. Duyster, R. M. Schmid, L. Eckmann, and M. Karin
NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta.
Cell 130:918
Geisel, J., F. Kahl, M. Muller, H. Wagner, C. J. Kirschning, I. B. Autenrieth, and J. S. Frick
IL-6 and Maturation Govern TLR2 and TLR4 Induced TLR Agonist Tolerance and Cross-Tolerance in Dendritic Cells.
J Immunol 179:5811
Gamrekelashvili, J., C. Kruger, R. von Wasielewski, M. Hoffmann, K. M. Huster, D. H. Busch, M. P. Manns, F. Korangy, and T. F. Greten
Necrotic tumor cell death in vivo impairs tumor-specific immune responses.
J Immunol 178:1573
Fuchs, M., C. Hermannstadter, P. Hutzler, G. Hacker, F. Haller, H. Hofler, and B. Luber
Deletion of exon 8 increases cisplatin-induced E-cadherin cleavage.
Exp Cell Res
Deppe, H., H. H. Horch, V. Schrodl, C. Haczek, and T. Miethke
Effect of 308-nm excimer laser light on peri-implantitis-associated bacteria-an in vitro investigation.
Lasers Med Sci 22:223
Daubeuf, B., J. Mathison, S. Spiller, S. Hugues, S. Herren, W. Ferlin, M. Kosco-Vilbois, H. Wagner, C. J. Kirschning, R. Ulevitch, and G. Elson
TLR4/MD-2 Monoclonal Antibody Therapy Affords Protection in Experimental Models of Septic Shock.
J Immunol 179:6107
Cosma, A., R. Nagaraj, C. Staib, C. Diemer, F. Wopfner, H. Schatzl, D. H. Busch, G. Sutter, F. D. Goebel, and V. Erfle
Evaluation of modified vaccinia virus Ankara as an alternative vaccine against smallpox in chronically HIV type 1-infected individuals undergoing HAART.
AIDS Res Hum Retroviruses 23:782
Bernhard, H., J. Neudorfer, K. Gebhard, H. Conrad, C. Hermann, J. Nahrig, F. Fend, W. Weber, D. H. Busch, and C. Peschel
Adoptive transfer of autologous, HER2-specific, cytotoxic T lymphocytes for the treatment of HER2-overexpressing breast cancer.
Cancer Immunol Immunother
Bauer, A., S. Kirschnek, and G. Hacker
Inhibition of apoptosis can be accompanied by increased Bim levels in T lymphocytes and neutrophil granulocytes.
Cell Death Differ 14:1714
Autenrieth, S. E., I. Soldanova, R. Rosemann, D. Gunst, N. Zahir, M. Kracht, K. Ruckdeschel, H. Wagner, S. Borgmann, and I. B. Autenrieth
Yersinia enterocolitica YopP inhibits MAP kinase-mediated antigen uptake in dendritic cells.
Cell Microbiol 9:425
Aly, S., T. Laskay, J. Mages, A. Malzan, R. Lang, and S. Ehlers
Interferon-gamma-dependent mechanisms of mycobacteria-induced pulmonary immunopathology: the role of angiostasis and CXCR3-targeted chemokines for granuloma necrosis
J Pathol 212:295
Stock KF, Birkenfeld G, Hann von Weyhern C, Stangl M, Prazeres da Costa C, Scmid RM, Lersch C.
Regulatory T cells primed in the absence of TLR2 fail to control Immunopathology and TH responses in Schistosomiasis.
Physiol. Genomics 30: 134-145 . March 2007
Layland LE, Rad R, Wagner H, da Costa CU
Oberbauchschmerz bei einer türkischen Patientin
Zeitschrift für Gastroenterologie, in review Jan 2007. January 2007