Institut für medizinische Mikrobiologie, Immunologie und Hygiene | Publications 2007

Publications 2007

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Zhu, X., A. Bagchi, H. Zhao, C. J. Kirschning, R. J. Hajjar, W. Chao, J. Hellman, and U. Schmidt
Toll-like receptor 2 activation by bacterial peptidoglycan-associated lipoprotein activates cardiomyocyte inflammation and contractile dysfunction.
Crit Care Med 35:886 2007

Zantl, N., G. Weirich, H. Zall, B. M. Seiffert, S. F. Fischer, S. Kirschnek, C. Hartmann, R. M. Fritsch, B. Gillissen, P. T. Daniel, and G. Hacker
Frequent loss of expression of the pro-apoptotic protein Bim in renal cell carcinoma: evidence for contribution to apoptosis resistance.
Oncogene 26:7038

Ying, S., and G. Hacker
Apoptosis induced by direct triggering of mitochondrial apoptosis proceeds in the near-absence of some apoptotic markers.
Apoptosis 12:2003

Wiethe, C., M. Schiemann, D. Busch, L. Haeberle, M. Kopf, G. Schuler, and M. B. Lutz
Interdependency of MHC class II/self-peptide and CD1d/self-glycolipid presentation by TNF-matured dendritic cells for protection from autoimmunity.
J Immunol 178:4908

Weber, A., S. A. Paschen, K. Heger, F. Wilfling, T. Frankenberg, H. Bauerschmitt, B. M. Seiffert, S. Kirschnek, H. Wagner, and G. Hacker
BimS-induced apoptosis requires mitochondrial localization but not interaction with anti-apoptotic Bcl-2 proteins.
J Cell Biol 177:625

Spiller, S., S. Dreher, G. Meng, A. Grabiec, W. Thomas, T. Hartung, K. Pfeffer, H. Hochrein, H. Brade, W. Bessler, H. Wagner, and C. J. Kirschning
Cellular recognition of trimyristoylated peptide or enterobacterial lipopolysaccharide via both TLR2 and TLR4.
J Biol Chem 282:13190

Schuster, I. G., D. H. Busch, E. Eppinger, E. Kremmer, S. Milosevic, C. Hennard, C. Kuttler, J. W. Ellwart, B. Frankenberger, E. Nossner, C. Salat, C. Bogner, A. Borkhardt, H. J. Kolb, and A. M. Krackhardt
Allorestricted T cells with specificity for the FMNL1-derived peptide PP2 have potent antitumor activity against hematologic and other malignancies.
Blood 110:2931

Schulz, C., A. Schafer, M. Stolla, S. Kerstan, M. Lorenz, M. L. von Bruhl, M. Schiemann, J. Bauersachs, T. Gloe, D. H. Busch, M. Gawaz, and S. Massberg
Chemokine fractalkine mediates leukocyte recruitment to inflammatory endothelial cells in flowing whole blood: a critical role for P-selectin expressed on activated platelets.
Circulation 116:764

Schmitz, F., A. Heit, S. Guggemoos, A. Krug, J. Mages, M. Schiemann, H. Adler, I. Drexler, T. Haas, R. Lang, and H. Wagner
Interferon-regulatory-factor 1 controls Toll-like receptor 9-mediated IFN-beta production in myeloid dendritic cells.
Eur J Immunol 37:315

Schleicher, U., J. Liese, I. Knippertz, C. Kurzmann, A. Hesse, A. Heit, J. A. Fischer, S. Weiss, U. Kalinke, S. Kunz, and C. Bogdan
NK cell activation in visceral leishmaniasis requires TLR9, myeloid DCs, and IL-12, but is independent of plasmacytoid DCs.
J Exp Med 204:893

Rupprecht, T. A., C. J. Kirschning, B. Popp, S. Kastenbauer, V. Fingerle, H. W. Pfister, and U. Koedel
Borrelia garinii induces CXCL13 production in human monocytes through Toll-like receptor 2.
Infect Immun 75:4351

Rubio-Aliaga, I., D. Soewarto, S. Wagner, M. Klaften, H. Fuchs, S. Kalaydjiev, D. H. Busch, M. Klempt, B. Rathkolb, E. Wolf, K. Abe, S. Zeiser, G. K. Przemeck, J. Beckers, and M. H. de Angelis
A genetic screen for modifiers of the delta1-dependent notch signaling function in the mouse.
Genetics 175:1451

Rodriguez, N., J. Mages, H. Dietrich, N. Wantia, H. Wagner, R. Lang, and T. Miethke
MyD88-dependent changes in the pulmonary transcriptome after infection with Chlamydia pneumoniae.
Physiol Genomics 30:134

Rad, R., L. Brenner, A. Krug, P. Voland, J. Mages, R. Lang, S. Schwendy, W. Reindl, A. Dossumbekova, W. Ballhorn, H. Wagner, R. M. Schmid, S. Bauer, and C. Prinz
Toll-like receptor-dependent activation of antigen-presenting cells affects adaptive immunity to Helicobacter pylori.
Gastroenterology 133:150

Paschen, S. A., A. Weber, and G. Hacker
Mitochondrial protein import: a matter of death?
Cell Cycle 6:2434

Oeder, S., J. Mages, P. Flicek, and R. Lang
Uncovering information on expression of natural antisense transcripts in Affymetrix MOE430 datasets.
BMC Genomics 8:200

Neuenhahn, M., and D. H. Busch
Unique functions of splenic CD8alpha(+) dendritic cells during infection with intracellular pathogens.
Immunol Lett

Neudorfer, J., B. Schmidt, K. M. Huster, F. Anderl, M. Schiemann, G. Holzapfel, T. Schmidt, L. Germeroth, H. Wagner, C. Peschel, D. H. Busch, and H. Bernhard
Reversible HLA multimers (Streptamers) for the isolation of human cytotoxic T lymphocytes functionally active against tumor- and virus-derived antigens.
J Immunol Methods 320:119

Merx, S., M. Neumaier, H. Wagner, C. J. Kirschning, and P. Ahmad-Nejad
Characterization and investigation of single nucleotide polymorphisms and a novel TLR2 mutation in the human TLR2 gene.
Hum Mol Genet 16:1225

Mayer, A. K., M. Muehmer, J. Mages, K. Gueinzius, C. Hess, K. Heeg, R. Bals, R. Lang, and A. H. Dalpke
Differential recognition of TLR-dependent microbial ligands in human bronchial epithelial cells.
J Immunol 178:3134

Lin, Y. H., J. Friederichs, M. A. Black, J. Mages, R. Rosenberg, P. J. Guilford, V. Phillips, M. Thompson-Fawcett, N. Kasabov, T. Toro, A. E. Merrie, A. van Rij, H. S. Yoon, J. L. McCall, J. R. Siewert, B. Holzmann, and A. E. Reeve
Multiple gene expression classifiers from different array platforms predict poor prognosis of colorectal cancer.
Clin Cancer Res 13:498

Lepenies, B., J. P. Cramer, G. D. Burchard, H. Wagner, C. J. Kirschning, and T. Jacobs
Induction of experimental cerebral malaria is independent of TLR2/4/9.
Med Microbiol Immunol

Lech, M., C. Garlanda, A. Mantovani, C. J. Kirschning, D. Schlondorff, and H. J. Anders
Different roles of TiR8/Sigirr on toll-like receptor signaling in intrarenal antigen-presenting cells and tubular epithelial cells.
Kidney Int 72:182

Layland, L. E., R. Rad, H. Wagner, and C. U. da Costa
Immunopathology in schistosomiasis is controlled by antigen-specific regulatory T cells primed in the presence of TLR2.
Eur J Immunol 37:2174

Lahl, K., C. Loddenkemper, C. Drouin, J. Freyer, J. Arnason, G. Eberl, A. Hamann, H. Wagner, J. Huehn, and T. Sparwasser
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease.
J Exp Med 204:57

Krishnan, L., K. Gurnani, C. J. Dicaire, H. van Faassen, A. Zafer, C. J. Kirschning, S. Sad, and G. D. Sprott
Rapid clonal expansion and prolonged maintenance of memory CD8+ T cells of the effector (CD44highCD62Llow) and central (CD44highCD62Lhigh) phenotype by an archaeosome adjuvant independent of TLR2.
J Immunol 178:2396

Koedel, U., U. M. Merbt, C. Schmidt, B. Angele, B. Popp, H. Wagner, H. W. Pfister, and C. J. Kirschning
Acute brain injury triggers MyD88-dependent, TLR2/4-independent inflammatory responses
Am J Pathol 171:200

Klein, M., C. Schmidt, S. Kastenbauer, R. Paul, C. J. Kirschning, H. Wagner, B. Popp, H. W. Pfister, and U. Koedel
MyD88-dependent immune response contributes to hearing loss in experimental pneumococcal meningitis.
J Infect Dis 195:1189

Kastenmuller, W., G. Gasteiger, J. H. Gronau, R. Baier, R. Ljapoci, D. H. Busch, and I. Drexler
Cross-competition of CD8+ T cells shapes the immunodominance hierarchy during boost vaccination.
J Exp Med 204:2187

Kaiser-Schulz, G., A. Heit, L. Quintanilla-Martinez, F. Hammerschmidt, S. Hess, L. Jennen, H. Rezaei, H. Wagner, and H. M. Schatzl
Polylactide-coglycolide microspheres co-encapsulating recombinant tandem prion protein with CpG-oligonucleotide break self-tolerance to prion protein in wild-type mice and induce CD4 and CD8 T cell responses.
J Immunol 179:2797

Heit, A., F. Schmitz, T. Haas, D. H. Busch, and H. Wagner
Antigen co-encapsulated with adjuvants efficiently drive protective T cell immunity.
Eur J Immunol 37:2063

Heit, A., D. H. Busch, H. Wagner, and F. Schmitz
Vaccine protocols for enhanced immunogenicity of exogenous antigens
Int J Med Microbiol

Hamm, S., A. Heit, M. Koffler, K. M. Huster, S. Akira, D. H. Busch, H. Wagner, and S. Bauer
Immunostimulatory RNA is a potent inducer of antigen-specific cytotoxic and humoral immune response in vivo.
Int Immunol 19:297

Hacker, G., and A. Weber
BH3-only proteins trigger cytochrome c release, but how?
Arch Biochem Biophys 462:150

Hacker, G., and S. A. Paschen
Therapeutic targets in the mitochondrial apoptotic pathway.
Expert Opin Ther Targets 11:515

Habib, S. J., T. Waizenegger, A. Niewienda, S. A. Paschen, W. Neupert, and D. Rapaport
The N-terminal domain of Tob55 has a receptor-like function in the biogenesis of mitochondrial beta-barrel proteins.
J Cell Biol 176:77

Greten, F. R., M. C. Arkan, J. Bollrath, L. C. Hsu, J. Goode, C. Miething, S. I. Goktuna, M. Neuenhahn, J. Fierer, S. Paxian, N. Van Rooijen, Y. Xu, T. O’Cain, B. B. Jaffee, D. H. Busch, J. Duyster, R. M. Schmid, L. Eckmann, and M. Karin
NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta.
Cell 130:918

Geisel, J., F. Kahl, M. Muller, H. Wagner, C. J. Kirschning, I. B. Autenrieth, and J. S. Frick
IL-6 and Maturation Govern TLR2 and TLR4 Induced TLR Agonist Tolerance and Cross-Tolerance in Dendritic Cells.
J Immunol 179:5811

Gamrekelashvili, J., C. Kruger, R. von Wasielewski, M. Hoffmann, K. M. Huster, D. H. Busch, M. P. Manns, F. Korangy, and T. F. Greten
Necrotic tumor cell death in vivo impairs tumor-specific immune responses.
J Immunol 178:1573

Fuchs, M., C. Hermannstadter, P. Hutzler, G. Hacker, F. Haller, H. Hofler, and B. Luber
Deletion of exon 8 increases cisplatin-induced E-cadherin cleavage.
Exp Cell Res

Deppe, H., H. H. Horch, V. Schrodl, C. Haczek, and T. Miethke
Effect of 308-nm excimer laser light on peri-implantitis-associated bacteria-an in vitro investigation.
Lasers Med Sci 22:223

Daubeuf, B., J. Mathison, S. Spiller, S. Hugues, S. Herren, W. Ferlin, M. Kosco-Vilbois, H. Wagner, C. J. Kirschning, R. Ulevitch, and G. Elson
TLR4/MD-2 Monoclonal Antibody Therapy Affords Protection in Experimental Models of Septic Shock.
J Immunol 179:6107

Cosma, A., R. Nagaraj, C. Staib, C. Diemer, F. Wopfner, H. Schatzl, D. H. Busch, G. Sutter, F. D. Goebel, and V. Erfle
Evaluation of modified vaccinia virus Ankara as an alternative vaccine against smallpox in chronically HIV type 1-infected individuals undergoing HAART.
AIDS Res Hum Retroviruses 23:782

Bernhard, H., J. Neudorfer, K. Gebhard, H. Conrad, C. Hermann, J. Nahrig, F. Fend, W. Weber, D. H. Busch, and C. Peschel
Adoptive transfer of autologous, HER2-specific, cytotoxic T lymphocytes for the treatment of HER2-overexpressing breast cancer.
Cancer Immunol Immunother

Bauer, A., S. Kirschnek, and G. Hacker
Inhibition of apoptosis can be accompanied by increased Bim levels in T lymphocytes and neutrophil granulocytes.
Cell Death Differ 14:1714

Autenrieth, S. E., I. Soldanova, R. Rosemann, D. Gunst, N. Zahir, M. Kracht, K. Ruckdeschel, H. Wagner, S. Borgmann, and I. B. Autenrieth
Yersinia enterocolitica YopP inhibits MAP kinase-mediated antigen uptake in dendritic cells.
Cell Microbiol 9:425

Aly, S., T. Laskay, J. Mages, A. Malzan, R. Lang, and S. Ehlers
Interferon-gamma-dependent mechanisms of mycobacteria-induced pulmonary immunopathology: the role of angiostasis and CXCR3-targeted chemokines for granuloma necrosis
J Pathol 212:295

Stock KF, Birkenfeld G, Hann von Weyhern C, Stangl M, Prazeres da Costa C, Scmid RM, Lersch C.
Regulatory T cells primed in the absence of TLR2 fail to control Immunopathology and TH responses in Schistosomiasis.
Physiol. Genomics 30: 134-145 . March 2007

Layland LE, Rad R, Wagner H, da Costa CU
Oberbauchschmerz bei einer türkischen Patientin
Zeitschrift für Gastroenterologie, in review Jan 2007. January 2007


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